CNL can refer to:

• Allensworth State Park station, California, United States, special-arrangement Amtrak station with code CNL
• Centre national du livre, French Government agency
• CNL Financial Group, previously Commercial Net Lease
• The National Literature Centre (French: Centre national de littérature), the national literary archive of Luxembourg
• The Commissioners of Northern Lighthouses, now known as the Northern Lighthouse Board
• Compute Node Linux, a Linux-based operating system used with Cray supercomputers
• Clinical nurse leader
• Columbia, Newberry and Laurens Railroad
• Controlled natural languages
• Computer Networks Laboratory
• CityNightLine, a former night train network in Germany and neighboring countries
• Sindal Airport, Denmark (IATA code CNL)
• Canley railway station, West Midlands, three letter station code
• Chronic neutrophilic leukemia
• Canadian Nuclear Laboratories, formerly the Chalk River Laboratories
• CONCACAF Nations League, an international association football competition involving the men's national teams of CONCACAF's member associations